Drug Standards
Apexbio Technology LLC Flumazenil 78755-81-4 25mg
Flumazenil (CAS 78755-81-4) is a centrally active small molecule that functions as a benzodiazepine receptor antagonist It binds to -aminobutyric acid type A (GABA sub A /sub ) receptors without preferential selectivity for subtypes containing 1 2 3 or 5 subunits By competitively inhibiting benzodiazepine binding at these receptors flumazenil modulates GABAergic neurotransmission in the central nervous system This compound is widely utilized in biomedical research to investigate benzodiazepine pharmacology GABA sub A /sub receptor function and the neural mechanisms underlying anxiolytic and sedative drug actions
Medchemexpress LLC Amoxicillin (trihydrate) mixture with potassium clavulanate (4:1) | 25 MG
Amoxicillin (trihydrate) mixture with potassium clavulanate (4:1) is an antibiotic characterized by good oral absorption and broad-spectrum antimicrobial activity. It functions by inhibiting the biosynthesis of polypeptides in the cell wall, thereby hindering cell growth.
- Good oral absorption
- Broad-spectrum antimicrobial activity
- Inhibits biosynthesis of polypeptides in the cell wall
- Inhibits cell growth
- For research use only
Medchemexpress LLC Neostigmine methyl sulfate | 51-60-5 | 98.9% | 100 MG
Neostigmine methyl sulfate (Standard) serves as an analytical standard, designed for research and analytical applications. This reference standard assay is widely utilized in qualitative, quantitative, and methodological research experiments, including techniques such as HPLC, GC, and MS.
- Intended for research and analytical applications.
- Functions as a reference standard supplied assay.
- Used in qualitative, quantitative, and methodological research.
- Suitable for techniques including HPLC, GC, and MS.
Medchemexpress LLC Mifepristone | 84371-65-3 | 99.9% | 429.59 | 1 ML
Mifepristone (RU486) is a progesterone receptor (PR) and glucocorticoid receptor (GR) antagonist with IC50s of 0.2 nM and 2.6 nM in in vitro assay. It was discovered as the first competitive progesterone antagonist, stimulating a search for more potent and selective antiprogestins.
- Progesterone receptor and glucocorticoid receptor antagonist
- Inhibits cell growth
- Potentiates doxorubicin-induced cytotoxicity in K562/R7 cells
- Reduces severity of EtOH withdrawal in vivo
Medchemexpress LLC Promazine hydrochloride | 53-60-1 | 99.9% | 1 ML
Promazine hydrochloride is an antipsychotic and a dopamine receptor D2 antagonist that inhibits dopaminergic neurotransmission. It is supplied as a solid, white to off-white powder.
- Antipsychotic and dopamine receptor D2 antagonist
- Inhibits dopaminergic neurotransmission
- Shows KDs of 25, 190, and 8400 nM at human norepinephrine, serotonin, and dopamine transporters
- Molecular weight: 320.88
- Chemical formula: C17H21ClN2S
- Soluble in water and DMSO at 100 mg/mL
Apexbio Technology LLC Fostamatinib (R788) 901119-35-5 100mg
Fostamatinib (R788 CAS 901119-35-5) is an orally available small-molecule inhibitor targeting spleen tyrosine kinase (Syk) with an IC50 of approximately 41 nM As a prodrug fostamatinib is rapidly converted to its active metabolite R406 an ATP-competitive inhibitor of Syk (Ki 30 nM) R406 additionally inhibits related kinases such as Flt3 Lyn (IC50 63 nM) and Lck (IC50 37 nM) thereby modulating BCR- and Fc receptor-mediated signaling pathways Preclinical studies demonstrate activity of fostamatinib in various autoimmune and inflammatory models including SLE-related nephritis and dermatitis in MRL/lpr mice highlighting its utility as a research tool in autoimmune disease investigation
Medchemexpress LLC Neriifolin | 466-07-9 | 1 MG
Neriifolin is a CNS-penetrating cardiac glycoside that functions as an inhibitor of Na+, K+-ATPase. It targets beclin 1, inhibiting the formation of LC3-associated phagosomes and ameliorating the development of experimental autoimmune encephalomyelitis (EAE). This compound induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells, making it suitable for laboratory research applications.
- CNS-penetrating cardiac glycoside
- Inhibitor of Na+, K+-ATPase
- Targets beclin 1
- Inhibits LC3-associated phagosome formation
- Ameliorates experimental autoimmune encephalomyelitis (EAE) development
- Induces cell cycle arrest and apoptosis in HepG2 cells
- Purity: 99.70%
- Appearance: Solid
- Color: White to yellow
- Molecular weight: 534.68
- Soluble in DMSO (100 mg/mL)
Medchemexpress LLC Methylprednisolone succinate (sodium) | 2375-03-3 | ≥95% | 5 MG
Methylprednisolone succinate sodium is a prodrug of Methylprednisolone and a glucocorticoid with immunosuppressant and anti-inflammatory activity. It binds cytosolic glucocorticoid receptors, translocates to nuclei, and modulates target gene transcription. This compound alters Bax, Bcl-2, occludin, and ZO-1 expression; attenuates TLR4/NF-κB signaling; and suppresses proinflammatory cytokine production and immune cell activation. It can be used for research of intracranial haemorrhage, rheumatoid arthritis, multiple sclerosis, preterminal cancer, inflammatory conditions, shock, immediate-type hypersensitivity, acute myocardial ischemia, hypoxic heart muscle damage, and traumatic spinal cord injury.
- Target: glucocorticoid receptor.
- Research areas: infection, neurological disease, inflammation/immunology, cancer.
- Immunosuppressant and anti-inflammatory activity.
Medchemexpress LLC Enalaprilat (dihydrate) | 84680-54-6 | 99.6% | 1 ML
Enalaprilat dihydrate (MK-422), the active metabolite of the oral proagent Enalapril, is a potent, competitive, and long-acting angiotensin-converting enzyme (ACE) inhibitor with an IC50 of 1.94 nM. This product is intended for research on hypertension.
- Potent and long-acting ACE inhibitor
- Attenuates IGF-I induced neonatal rat cardiac fibroblast growth in vitro
- Shows significant intraocular pressure (IOP)-lowering effect in rabbits in vivo
Medchemexpress LLC Diclofenac epolamine | 119623-66-4 | 100.0% | 411.32 | 50 MG
Diclofenac epolamine is a non-steroidal anti-inflammatory drug (NSAID) used for relieving arthritis pain, acute pain, osteoarthritis, and actinic keratosis. It demonstrates good skin absorption characteristics without local adverse reactions or allergies.
- Relieves arthritis pain, acute pain, osteoarthritis, and actinic keratosis.
- Demonstrates good skin absorption characteristics.
- Does not cause local adverse reactions or allergies.
- Effective in treating inflammatory conditions.
- Increases partitioning into the skin.
- Enhances and sustains drug transport through the skin.
Medchemexpress LLC Naphazoline nitrate | 5144-52-5 | MFCD00014316 | 99.1% | 273.29 | 50 MG
Naphazoline nitrate is an α-adrenergic receptor agonist that reduces vascular hyperpermeability and promotes vasoconstriction. It is also known to reduce levels of inflammatory factors, cytokines, IgE, GMCSF, and NGF, making it suitable for non-bacterial conjunctivitis research.
- α-adrenergic receptor agonist
- Reduces vascular hyperpermeability
- Promotes vasoconstriction
- Reduces levels of inflammatory factors (TNF-α, IL-1β, IL-6)
- Reduces levels of cytokines (IFN-γ, IL-4)
- Reduces IgE, GMCSF, and NGF
- Can be used for non-bacterial conjunctivitis research
Medchemexpress LLC Naphazoline nitrate | 5144-52-5 | 99.1% | 273.29 | 100 MG
Naphazoline nitrate is an α-adrenergic receptor agonist that reduces vascular hyperpermeability and promotes vasoconstriction. It also reduces levels of inflammatory factors and can be used for non-bacterial conjunctivitis research.
- Targets α-adrenergic receptors
- Helps manage vascular issues
- Decreases levels of TNF-α, IL-1β, IL-6, IFN-γ, IL-4, IgE, GMCSF, and NGF
- Applicable for non-bacterial conjunctivitis research
- Solid, white to off-white appearance
- Solubility: 100 mg/mL in DMSO
Medchemexpress LLC Gemcitabine monophosphate disodium | 1638288-31-9 | 387.14 | 10 MM * 1 ML
Gemcitabine monophosphate (Gemcitabine 5′-phosphate) is one of the active intermediates of Gemcitabine. It has a synergistic anti-cancer effect and can be delivered by formulating it into nanoparticles.
- Active intermediate of Gemcitabine.
- Synergistic anti-cancer effect.
- Can be delivered via nanoparticles.
- In vivo studies show it induces tumor cell apoptosis (30-40%), reduces tumor cell proliferation by 8 times, significantly reduces tumor microvessel density (MVD), and inhibits tumor mitosis in subcutaneous and orthotopic xenograft mouse models of non-small cell lung cancer.